Virologically Confirmed Population-Based Burden of Hospitalization Caused by Influenza A and B among Children in Hong Kong
Identifieur interne : 002C00 ( Main/Exploration ); précédent : 002B99; suivant : 002C01Virologically Confirmed Population-Based Burden of Hospitalization Caused by Influenza A and B among Children in Hong Kong
Auteurs : Susan S. Chiu [Hong Kong] ; Kwok-Hung Chan [Hong Kong] ; Hong Chen [Hong Kong] ; Betty W. Young [Hong Kong] ; Wilina Lim [Hong Kong] ; Wilfred Hing Sang Wong [Hong Kong] ; Yu Lung Lau [Hong Kong] ; J. S. Malik Peiris [Hong Kong]Source :
- Clinical Infectious Diseases [ 1058-4838 ] ; 2009.
Abstract
Background.We sought to determine the virologically confirmed hospitalization rates associated with influenza virus infection among Hong Kong children. Methods.Patients <18 years of age who lived on Hong Kong Island (a separate island within Hong Kong) and were admitted to either of the only 2 public hospitals on the island for a febrile acute respiratory infection on 1 fixed day of the week in each hospital from October 2003 through September 2006 were prospectively recruited. These 2 hospitals together accounted for 72.5% of all general pediatric admissions in Hong Kong Island with a known population denominator. Nasopharyngeal aspirates were obtained from all recruited patients and were tested for influenza A and influenza B viruses by direct antigen detection and culture. Results.All cases of influenza A during 2003–2004 were caused by H3N2 virus, whereas 85.7% of cases during 2004–2005 were due to H3N2 virus, and 93.5% during 2005–2006 were due to H1N1 virus. During 2004–2005, infants <1 year of age had the highest rate of hospitalization for influenza A (103.8 cases per 10,000 population), whereas children 1 year of age had the highest rate of hospitalization during the other 2 seasons (95.5 and 54.6 cases per 10,000 population during 2003–2004 and 2005–2006, respectively). A protection rate of 25%, presumably attributable to maternal antibodies, was seen in infants <1 year of age who were hospitalized during 2003–2004 with infection due to an H3N2 virus that had been in circulation. The hospitalization rates for influenza B were highest among children 2–4 years of age. Conclusions.This population-based study of hospitalizations due to virologically confirmed influenza demonstrated a very high burden of disease among young children in Hong Kong. The morbidity varied with virus type, subtype, and antigenic variants.
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DOI: 10.1086/605570
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Young</name></author><author><name sortKey="Lim, Wilina" sort="Lim, Wilina" uniqKey="Lim W" first="Wilina" last="Lim">Wilina Lim</name></author><author><name sortKey="Wong, Wilfred Hing Sang" sort="Wong, Wilfred Hing Sang" uniqKey="Wong W" first="Wilfred Hing Sang" last="Wong">Wilfred Hing Sang Wong</name></author><author><name sortKey="Lau, Yu Lung" sort="Lau, Yu Lung" uniqKey="Lau Y" first="Yu Lung" last="Lau">Yu Lung Lau</name></author><author><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. 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Chiu</name><affiliation wicri:level="1"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine</wicri:regionArea></affiliation></author><author><name sortKey="Chan, Kwok Hung" sort="Chan, Kwok Hung" uniqKey="Chan K" first="Kwok-Hung" last="Chan">Kwok-Hung Chan</name><affiliation wicri:level="1"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Microbiology, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Hong" sort="Chen, Hong" uniqKey="Chen H" first="Hong" last="Chen">Hong Chen</name><affiliation wicri:level="1"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital</wicri:regionArea><wicri:noRegion>Pamela Youde Nethersole Eastern Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Young, Betty W" sort="Young, Betty W" uniqKey="Young B" first="Betty W." last="Young">Betty W. Young</name><affiliation wicri:level="1"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital</wicri:regionArea><wicri:noRegion>Pamela Youde Nethersole Eastern Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Lim, Wilina" sort="Lim, Wilina" uniqKey="Lim W" first="Wilina" last="Lim">Wilina Lim</name><affiliation wicri:level="1"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Virology Division, Public Health Laboratory Services Branch, Centre for Health Protection</wicri:regionArea><wicri:noRegion>Centre for Health Protection</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Wilfred Hing Sang" sort="Wong, Wilfred Hing Sang" uniqKey="Wong W" first="Wilfred Hing Sang" last="Wong">Wilfred Hing Sang Wong</name><affiliation wicri:level="1"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine</wicri:regionArea></affiliation></author><author><name sortKey="Lau, Yu Lung" sort="Lau, Yu Lung" uniqKey="Lau Y" first="Yu Lung" last="Lau">Yu Lung Lau</name><affiliation wicri:level="1"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine</wicri:regionArea></affiliation></author><author><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name><affiliation wicri:level="1"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Microbiology, The University of Hong Kong</wicri:regionArea><wicri:noRegion>The University of Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Hong Kong University Pasteur Research Centre, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Hong Kong</country></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Hong Kong</country><wicri:regionArea>Reprints or correspondence: Dr. J. S. Malik Peiris, Dept. of Microbiology, University Pathology Building, Queen Mary Hospital, Pokfulam</wicri:regionArea><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Infectious Diseases</title><title level="j" type="abbrev">Clinical Infectious Diseases</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published">2009</date><biblScope unit="vol">49</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1016">1016</biblScope><biblScope unit="page" to="1021">1021</biblScope></imprint><idno type="ISSN">1058-4838</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background.We sought to determine the virologically confirmed hospitalization rates associated with influenza virus infection among Hong Kong children. Methods.Patients <18 years of age who lived on Hong Kong Island (a separate island within Hong Kong) and were admitted to either of the only 2 public hospitals on the island for a febrile acute respiratory infection on 1 fixed day of the week in each hospital from October 2003 through September 2006 were prospectively recruited. These 2 hospitals together accounted for 72.5% of all general pediatric admissions in Hong Kong Island with a known population denominator. Nasopharyngeal aspirates were obtained from all recruited patients and were tested for influenza A and influenza B viruses by direct antigen detection and culture. Results.All cases of influenza A during 2003–2004 were caused by H3N2 virus, whereas 85.7% of cases during 2004–2005 were due to H3N2 virus, and 93.5% during 2005–2006 were due to H1N1 virus. During 2004–2005, infants <1 year of age had the highest rate of hospitalization for influenza A (103.8 cases per 10,000 population), whereas children 1 year of age had the highest rate of hospitalization during the other 2 seasons (95.5 and 54.6 cases per 10,000 population during 2003–2004 and 2005–2006, respectively). A protection rate of 25%, presumably attributable to maternal antibodies, was seen in infants <1 year of age who were hospitalized during 2003–2004 with infection due to an H3N2 virus that had been in circulation. The hospitalization rates for influenza B were highest among children 2–4 years of age. Conclusions.This population-based study of hospitalizations due to virologically confirmed influenza demonstrated a very high burden of disease among young children in Hong Kong. The morbidity varied with virus type, subtype, and antigenic variants.</div></front></TEI><affiliations><list><country><li>Hong Kong</li></country></list><tree><country name="Hong Kong"><noRegion><name sortKey="Chiu, Susan S" sort="Chiu, Susan S" uniqKey="Chiu S" first="Susan S." last="Chiu">Susan S. Chiu</name></noRegion><name sortKey="Chan, Kwok Hung" sort="Chan, Kwok Hung" uniqKey="Chan K" first="Kwok-Hung" last="Chan">Kwok-Hung Chan</name><name sortKey="Chen, Hong" sort="Chen, Hong" uniqKey="Chen H" first="Hong" last="Chen">Hong Chen</name><name sortKey="Lau, Yu Lung" sort="Lau, Yu Lung" uniqKey="Lau Y" first="Yu Lung" last="Lau">Yu Lung Lau</name><name sortKey="Lim, Wilina" sort="Lim, Wilina" uniqKey="Lim W" first="Wilina" last="Lim">Wilina Lim</name><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name><name sortKey="Wong, Wilfred Hing Sang" sort="Wong, Wilfred Hing Sang" uniqKey="Wong W" first="Wilfred Hing Sang" last="Wong">Wilfred Hing Sang Wong</name><name sortKey="Young, Betty W" sort="Young, Betty W" uniqKey="Young B" first="Betty W." last="Young">Betty W. Young</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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